Vielleicht fragst du dich, warum NO eine so wichtige Rolle für deine Gesundheit spielt?
Wirkt regulierend bei Bluthochdruck
Kann Alzheimer vorbeugen
Bekämpft Infektionen
Verlangsamt die Gefäßalterung
Schützt vor Karies
Vermindert toxische Cholesterinprodukte
Erfahre im Newsletter, wie du dein optimales NO-Level erreichen kannst!
Todesursache Nr. 1: Herz-Kreislauf Erkrankungen.
Bewegungsarmut und ungesunde bzw. „falsche“ Ernährung sind die Ursache für viele Krankheiten wie Übergewicht, Bluthochdruck, Glukose-Stoffwechselstörung und die Insulinresistenz bei Diabetikern. Dies führt zu einer schnelleren Gefäßalterung sowie Stoffwechselstörungen und somit zu schwerwiegenden Herz-Kreislauferkrankungen.
Das Problem verschärft sich mit dem Alter, da aufgrund der zunehmenden Ablagerungen in den Gefäßwänden unter anderem die Fähigkeit des Körpers NO (Nitric Oxide) selbst zu produzieren stark abnimmt. Daher ist es wichtig auf die Gefäßgesundheit zu achten.
Studien
Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A. Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite. Hypertension. 2008 Mar;51(3):784-90. Epub 2008 Feb 4.
Wink DA, Paolocci N. Mother Was Right: Eat Your Vegetables and Do Not Spit! When Oral Nitrate Helps With High Blood Pressure. Hypertension. 2008 Mar;51(3):617-9. Epub 2008 Feb 4.
Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans. Vanhatalo A, Blackwell JR, L’Heureux JE, Williams DW, Smith A, van der Giezen M, Winyard PG, Kelly J, Jones AM. Free Radic Biol Med. 2018 Aug 20;124:21-30.
Frequency of Tongue Cleaning Impacts the Human Tongue Microbiome Composition and Enterosalivary Circulation of Nitrate. Tribble GD, Angelov N, Weltman R, Wang BY, Eswaran SV, Gay IC, Parthasarathy K, Dao DV, Richardson KN, Ismail NM, Sharina IG, Hyde ER, Ajami NJ, Petrosino JF, Bryan NS. Front Cell Infect Microbiol. 2019 Mar 1;9:39.
Liddle L, Burleigh MC, Monaghan C, Muggeridge DJ, Sculthorpe N, Pedlar CR, Butcher J, Henriquez FL, Easton C. Variability in nitrate-reducing oral bacteria and nitric oxide metabolites in biological fluids following dietary nitrate administration: An assessment of the critical difference. Nitric Oxide. 2019 Feb 1;83:1-10.
Burleigh MC, Liddle L, Monaghan C, Muggeridge DJ, Sculthorpe N, Butcher JP, Henriquez FL, Allen JD, Easton C. Saliva nitrite production is elevated in individuals with a higher abundance of oral nitrate-reducing bacteria. Free Radic Biol Med. 2018 May 20;120:80-88.
Woessner M, Smoliga JM, Tarzia B, Stabler T, Van Bruggen M, Allen JD. Stepwise reduction in plasma and salivary nitrite with increasing strengths of mouthwash following a dietary nitrate load. Nitric Oxide. 2016 Apr 1;54:1-7.
Effects of dietary nitrate supplementation, from beetroot juice, on blood pressure in hypertensive pregnant women: A randomised, double-blind, placebo-controlled feasibility trial. Ormesher L, Myers JE, Chmiel C, Wareing M, Greenwood SL, Tropea T, Lundberg JO, Weitzberg E, Nihlen C, Sibley CP, Johnstone ED, Cottrell EC.
Nitric Oxide. 2018 Nov 1;80:37-44.
The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Govoni M, Jansson EA, Weitzberg E, Lundberg JO.
Nitric Oxide. 2008 Dec;19(4):333-7.
Nitrate-Rich Vegetables Increase Plasma Nitrate and Nitrite Concentrations and Lower Blood Pressure in Healthy Adults. Jonvik KL, Nyakayiru J, Pinckaers PJ, Senden JM, van Loon LJ, Verdijk LB. J Nutr. 2016 May;146(5):986-93.
Influence of dietary nitrate food forms on nitrate metabolism and blood pressure in healthy normotensive adults. McDonagh STJ, Wylie LJ, Webster JMA, Vanhatalo A, Jones AM. Nitric Oxide. 2018 Jan 30;72:66-74.
Sustaining elevated levels of nitrite in the oral cavity through consumption of nitrate-rich beetroot juice in young healthy adults reduces salivary pH. Hohensinn B, Haselgrübler R, Müller U, Stadlbauer V, Lanzerstorfer P, Lirk G, Höglinger O, Weghuber J. Nitric Oxide. 2016 Nov 30;60:10-15.
Govoni M, Jansson EA, Weitzberg E, Lundberg JO. The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Nitric Oxide. 2008 Dec;19(4):333-7. Epub 2008 Aug 30.
LJ Wylie, J Kelly, SJ Bailey, JR Blackwell, PF Skiba, PG Winyard, AE Jeukendrup, A Vanhatalo, AM Jones. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013 Aug 1;115(3):325-36.
NF Hord, Y Tang, NS Bryan. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 2009 Jul;90(1):1-10.
S Lidder, AJ Webb. Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway. Br J Clin Pharmacol. 2013 Mar;75(3):677-96.
T D Presley, A R Morgan, E Bechtold, W Clodfelter, R W Dove, J M Jennings, R A Kraft, S B King, P J Laurienti, W J R ejeski, J H Burdette, D B Kim-Shapiro, G D Miller. Acute effect of a high nitrate diet on brain perfusion in older adults. Nitric Oxide. 2011 Jan 1;24(1):34-42.
A A Kenjale, K L Ham, T Stabler, J L Robbins, J L Johnson, M Vanbruggen, G Privette, E Yim, W E Kraus, J D Allen. Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. J Appl Physiol (1985). 2011 Jun;110(6):1582-91.
M Murphy, K Eliot, R M Heuertz, E Weiss. Whole beetroot consumption acutely improves running performance. J Acad Nutr Diet. 2012 Apr;112(4):548-52.
M J Berry, N W Justus, J I Hauser, A H Case, C C Helms, S Basu, Z Rogers, M T Lewis, G D Miller. Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients. Nitric Oxide. 2015 Aug 1;48:22-30.
A Jajja, A Sutyarjoko, J Lara, K Rennie, K Brandt, O Qadir, M Siervo. Beetroot supplementation lowers daily systolic blood pressure in older, overweight subjects. Nutr Res. 2014 Oct;34(10):868-75.
V Kapil, R S Khambata, A Robertson, M J Caulfield, A Ahluwalia. Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension. 2015 Feb;65(2):320-7.
E Weitzberg, J O Lundberg. Novel aspects of dietary nitrate and human health. Annu Rev Nutr. 2013;33:129-59.
M P Hezel, E Weitzberg. The oral microbiome and nitric oxide homoeostasis. Oral Dis. 2015 Jan;21(1):7-16.
N S Bryan. Pharmacological therapies, lifestyle choices and nitric oxide deficiency: a perfect storm. Pharmacol Res. 2012 Dec;66(6):448-56.
C P Bondonno, K D Croft, I B Puddey, M J Considine, X Yang, N C Ward, J M Hodgson. Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy women. Food Funct. 2012 May;3(5):522-7.
W T Clements, S R Lee, R J Bloomer. Nitrate ingestion: a review of the health and physical performance effects. Nutrients. 2014 Nov 18;6(11):5224-64.
F J Larsen, T A Schiffer, S Borniquel, K Sahlin, B Ekblom, J O Lundberg, E Weitzberg. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab. 2011 Feb 2;13(2):149-59.
M Murphy, K Eliot, R M Heuertz, E Weiss. Whole beetroot consumption acutely improves running performance. J Acad Nutr Diet. 2012 Apr;112(4):548-52.
D A Hobbs, M G Goulding, A Nguyen, T Malaver, C F Walker, T W George, L Methven, J A Lovegrove. Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial. J Nutr. 2013 Sep;143(9):1399-405.
V Bond Jr, B H Curry, R G Adams, R M Millis, G E Haddad. Cardiorespiratory function associated with dietary nitrate supplementation. Appl Physiol Nutr Metab. 2014 Feb; 39(2): 168–172.
